Our
Science
Unveiling a novel approach for cardiovascular risk detection
By assessing arterial stiffness with our proprietary technology
See Clinical Evidence
Aiming to transform and save patients lives, we strive to develop a novel approach for cardiovascular risk stratification.
Aging in health and disease
We age in
curves not in lines
We age in spurts, driven by acute events that gradually increase arterial stiffness. It could be ten years of chronic stress, five years of obesity, or a decade of smoking. These factors create a gap between vascular age and chronological age — helping explain why some people age well, while others do not.
“A man is as old as his arteries.”
— Thomas Sydenham
Clinical approach
Detecting
early vascular aging
Detect early markers of subclinical vascular alteration in aging to inform proactive decision-making and engage in personalized treatment strategies for the long-term health and quality of life of your patients.
Aging in health and disease
We age in
curves not in lines
We age in spurts, driven by acute events that gradually increase arterial stiffness. It could be ten years of chronic stress, five years of obesity, or a decade of smoking. These factors create a gap between vascular age and chronological age — helping explain why some people age well, while others do not.
Clinical approach
Detecting
early vascular aging
Detect early markers of subclinical vascular alteration in aging to inform proactive decision-making and engage in personalized treatment strategies for the long-term health and quality of life of your patients.
Biomarker
Aortic stiffness leads
to vascular aging
Aortic stiffness is a major risk factor for cardiovascular disease and an independent predictor of cardiovascular mortality.
Systemic impact of high central vascular stiffness
Changes in aortic stiffness have high pathophysiological relevance, as they can lead to increased aortic pulse pressure and cardiac afterload, potentially resulting in damage to multiple organs.
Heart
Myocardial Dysfunction, Heart Failure, Left Arterial Dysfunction and Reduced Coronary Flow Reserve
Brain
Subclinical Brain, Pathology Cognitive
and Impairment / Dementia
Liver
Insulin Resistance and NASH
Kidney
Chronic Kidney Disease
Testicles
Testosterone Deficiency
Placenta-Fetal
Pre-Eclampsia Intrauterine Growth Restriction
The challenge of predicting such damage lies in the ability to personalize the quantification of the earliest signs of arterial stiffness alterations.
Until now, existing approaches (such as applanation tonometry) have offered only a global screening of arterial stiffness, providing an estimate along the carotid–femoral artery path without accounting for the often tortuous anatomy of the vessels.
That is exactly where our technology comes into play. We provide the most validated and precise stiffness biomarkers using MRI imaging.
How we do itThe core of our biomarker
Measurement of ascending aortic distensibility by MRI
Ascending Aortic Distensibility (AAD) measures the stiffness of the central arteries —the strongest predictor of cardiovascular events over 8.5 years in low- to intermediate-risk patients, using traditional risk factors.
Prime determinant of cardiovascular efficiency
Integrator of individual CV age and health over the lifespan
Biomarker of CV risk: early subclinical disease, primary and secondary prevention
Reversibility through therapeutic and non-therapeutic programs
Measured by MRI: unique non-invasive assessment of the central arterial system
Beyond these programs, we aim to fully leverage our platform’s potential by building a diversified portfolio of assets across various clinical applications
Vascular Diseases
Cardiac Diseases
Brain Diseases
Further Diseases
2024
CMR 4-142 – CMR Ascending Aortic Distensibility in Patients with Degenerative Aortic Aneurysm
Journal of Cardiovascular Magnetic Resonance
2022
Study protocol: MyoFit46—the cardiac sub-study of the MRC National Survey of Health and Development
BMC Cardiovascular Disorders
2022
Deep Learning-based Automated Aortic Area and Distensibility Assessment: the Multi-Ethnic Study of Atherosclerosis (MESA)
Journal of Digital Imaging
2021
Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers
JACC: CARDIOVASCULAR IMAGING
2020
Training for a First-Time Marathon Reverses Age-Related Aortic Stiffening
Journal of the American College of Cardiology
2020
Relationship between aortic distensibility and aortic regurgitation assessed by CMR in bicuspid valve patients
European Heart Journal-Cardiovascular Imaging
2020
Reduced proximal aortic distensibility is related to recurrent ischemic events in premature coronary artery disease
European Heart Journal
2019
Transfer Learning for Automated Aortic Segmentation and Assessment of Aortic Mechanics in Tetralogy of Fallot: Multi-Ethnic Study of Atherosclerosis and the German Competence Network for Congenital Heart Defects
Circulation
2019
Actigraphy based sleep characteristics and aortic stiffness: The Multi-Ethnic Study of Atherosclerosis (MESA)
Journal of the American Society of Hypertension
2019
Automated Aortic Analysis Using MRI and Deep Learning: The Multi-Ethnic Study of Atherosclerosis (MESA)
Circulation
2019
Changes in segmental pulse wave velocity of the thoracic aorta with age and left ventricular remodelling. An MRI 4D flow study
Journal of Hypertension
2019
Comparison of different methods for the estimation of aortic pulse wave velocity from 4D flow cardiovascular magnetic resonance
Journal of Cardiovascular Magnetic Resonance
2019
Left ventricular and proximal aorta coupling in magnetic resonance imaging: aging together?
American Journal of Physiology
2019
Obstructive Sleep Apnea and Structural/Functional Properties of the Thoracic Ascending Aorta: The Multi-Ethnic Study of Atherosclerosis (MESA)
Cardiology
2019
Proximal aorta longitudinal strain predicts aortic root dilation rate and aortic events in Marfan syndrome
European Heart Journal
2019
Role of Central Blood Pressure and Arterial Stiffening
Hypertension and Heart Failure
2018
Enhanced fitness relates to reduced cerebrovascular reactivity and perfusion in a sample of very healthy older adults
bioRxiv
2018
3D aortic morphology and stiffness in MRI using semi-automated cylindrical active surface provides optimized description of the vascular effects of aging and hypertension
Computers in Biology and Medicine
2018
Differential impact of local and regional aortic stiffness on left ventricular remodeling: a cardiovascular magnetic resonance study
Journal of Hypertension
2018
Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular Events: The MESA (Multi-Ethnic Study of Atherosclerosis).
Hypertension
2018
Relation of Sex Hormone Levels With Prevalent and 10-Year Change in Aortic Distensibility Assessed by MRI: The Multi-Ethnic Study of Atherosclerosis
American Journal of Hypertension
2017
Healthy aging of the left ventricle in relationship to cardiovascular risk factors: The Multi-Ethnic Study of Atherosclerosis (MESA)
PLoS ONE
2017
Effects of renal denervation on vascular remodelling in patients with heart failure and preserved ejection fraction: A randomised control trial
JRSM Cardiovascular Disease
2017
The assessment of aortic pulse wave velocity using 4D flow magnetic resonance imaging: Methods comparison
Computing in Cardiology
2017
A phantom study to evaluate the effects of a local sectional stiffness on aortic hemodynamics
Biomedical Physics & Engineering Express
2016
Reproducibility of functional aortic analysis using magnetic resonance imaging: the MESA
Eur Heart J Cardiovasc Imaging
2016
Ten-year longitudinal change in aortic stiffness assessed by cardiac MRI in the second half of the human lifespan: the multi-ethnic study of atherosclerosis.
European Heart Journal Cardiovascular Imaging
2016
Relationships between retinal arteriole anatomy and aortic geometry and function and peripheral resistance in hypertensives
Hypertension Research
2016
Relationship between tissue factor pathway inhibitor and aortic stiffness assessed by MRI: the Multi-Ethnic Study of Atherosclerosis (MESA)
Journal of Cardiovascular Magnetic Resonance
2016
Pulmonary Artery Stiffness Is Independently Associated with Right Ventricular Mass and Function: A Cardiac MR Imaging Study
Radiology
2016
Magnetic resonance and applanation tonometry for noninvasive determination of left ventricular load and ventricular vascular coupling in the time and frequency domain
Journal of hypertension
2016
Association of Aortic Stiffness With Left Ventricular Remodeling and Reduced Left Ventricular Function Measured by Magnetic Resonance Imaging The Multi-Ethnic Study of Atherosclerosis
Cardiovascular Imaging
2016
Abnormalities in aortic properties: a potential link between left ventricular diastolic function and ventricular—aortic coupling in sickle cell disease
The International Journal of Cardiovascular Imaging
2015
How variable is aortic strain measurement using magnetic resonance imaging?
European Congress of Radiology ECR 2015.
2015
Three dimensional modelling of the effect of arterial pulse wave velocity and body size on left ventricular geometry
Journal of Cardiovascular Magnetic Resonance
2015
Reproducibility of functional aortic analysis using magnetic resonance imaging: the MESA.
European Heart Journal – Cardiovascular Imaging
2015
Pulse Wave Velocity and Central Blood Pressure
Assessment of Preclinical Organ Damage in Hypertension
2015
Lessons on Quality Control in Large Scale Imaging Trials: the Multi-Ethnic Study of Atherosclerosis (MESA)
Current Cardiovascular Imaging Reports
2015
Left ventricular-aortic coupling in sickle cell disease underlies diastolic dysfunction
2015 Computing in Cardiology Conference
2015
Hearts and minds: linking vascular rigidity and aerobic fitness with cognitive aging
Neurobiology of Aging
2015
Gender Differences in Age-Related Aortic Elongation and Dilatation: Longitudinal Results From the Multiethnic Study of Atherosclerosis
Circulation
2015
Feasibility and comparison of left ventricular ejection flow acceleration recorded by cardiac magnetic resonance in patients with dilated cardiomyopathy: a case-control study
Journal of Cardiovascular Magnetic Resonance
2015
Evolution of aortic wall thickness and stiffness with atherosclerosis: long-term follow up from the multi-ethnic study of atherosclerosis.
Hypertension
2015
Estimation of aortic pulse wave transit time in cardiovascular magnetic resonance using complex wavelet cross-spectrum analysis
Computing in Cardiology
2014
Magnetic resonance imaging measures of decreased aortic strain and distensibility are proportionate to insulin resistance in adolescents with type 1 diabetes mellitus.
Pediatric Diabetes
2014
Aortic biomechanics by magnetic resonance: Early markers of aortic disease in Marfan syndrome regardless of aortic dilatation?
International Journal of Cardiology
2014
Association of aortic wall thickness with stiffness in the Multi-Ethnic Study of Atherosclerosis (MESA)
Journal of Cardiovascular Magnetic Resonance
2014
Caractérisation hémodynamique de l’aorte thoracique par IRM, tonométrie d’applanation et simulations numériques
Thesis
2014
Descending aorta subject-specific one-dimensional model validated against in vivo data
Journal of Biomechanics
2014
Evaluation of aortic flow alterations using MRI: Associations with left ventricular remodeling
Computing in Cardiology
2014
Geometry is a major determinant of flow reversal in proximal aorta.
American Journal of Physiology
2014
MR and applanation tonometry derived aortic impedance: Association with aging and left ventricular remodeling
Journal of Magnetic Resonance Imaging+E309
2014
Proximal Aortic Distensibility is an Independent Predictor of All-cause Mortality and Incident Cardiovascular Events in the Multi-Ethnic Study of Atherosclerosis
Journal of the American College of Cardiology
2013
Going beyond ejection fraction – CMR assessment of ventricular-vascular coupling and LV remodeling predicts diastolic dysfunction in advanced ischemic cardiomyopathy
Journal of Cardiovascular Magnetic Resonance
2013
Intraventricular ejection pressure gradient derived from acceleration measurement by phase contrast CMR as a new marker of left ventricular contractility: feasibility study and preliminary results in dilated cardiomyopathy
Journal of Cardiovascular Magnetic Resonance
2013
Numerical modeling of arterial pulse wave propagation to characterize aortic hemodynamic: Validation using magnetic resonance data
IRBM
2013
Right ventricular systolic dysfunction in patients with severe ischemic cardiomyopathy – CMR insights into an interventricular relationship
Journal of Cardiovascular Magnetic Resonance
2013
Structure and function of the ascending aorta in palliated transposition of the great arteries
International journal of cardiology
2012
Age-Related Changes in Aortic Arch Geometry: Relationship with Proximal Aortic Function and Left Ventricular Mass and Remodeling
Journal of the American College of Cardiology
2012
Aortic backward flow indices estimated from phase-contrast cardiovascular magnetic resonance data
Computing in Cardiology
2012
AORTIC BIOMECHANICS BY MRI: RELATION WITH AGE, GENDER AND TRADITIONAL CARDIOVASCULAR RISK FACTORS. A CROSS-SECTIONAL AND LONGITUDINAL STUDY: THE MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)
Journal of the American College of Cardiology
2012
Aortic Distensibility, Assessed by MRI, is Decreased in Adolescents with Type 1 Diabetes Mellitus and Elevated LDL-C
Circulation
2012
Aortic size, distensibility, and pulse wave velocity changes with aging: longitudinal analysis from Multi-Ethnic Study of Atherosclerosis (MESA)
Journal of Cardiovascular Magnetic Resonance
2012
Ascending aorta backward flow parameters estimated from phase-contrast cardiovascular magnetic resonance data: new indices of arterial aging
Computing in Cardiology
2012
The association between aortic stiffness parameters and left ventricular deformation: preliminary results from the MESA 5 study
Journal of Cardiovascular Magnetic Resonance
2011
Measurement of aortic arch pulse wave velocity in cardiovascular MR: Comparison of transit time estimators and description of a new approach
Journal of Magnetic Resonance Imaging
2011
Estimation of aortic distensibility from steady-state free-precession and phase contrast magnetic resonance images
IRBM
2011
Consistency of aortic distensibility and pulse wave velocity estimates with respect to the Bramwell-Hill theoretical model: a cardiovascular magnetic resonance study
Journal of Cardiovascular Magnetic Resonance
2011
Can a single phase contrast aortic flow acquisition be used to define a surrogate marker of cardiac index?
Proc. Int. Soc. Magn. Reson. Med
2010
Reduced Ascending Aortic Strain and Distensibility Earliest Manifestations of Vascular Aging in Humans
Hypertension
2010
Measurement of the aortic pulse wave velocity in MRI: Comparison of transit time estimators
Computing in Cardiology
2010
Comparison of aortic lumen area and distensibility using cine and phase contrast acquisitions
Computing in Cardiology
2010
Automated segmentation of the aorta from phase contrast MR images: Validation against expert tracing in healthy volunteers and in patients with a dilated aorta
Journal of Magnetic Resonance Imaging
2010
Automated left ventricular diastolic function evaluation from phase-contrast cardiovascular magnetic resonance and comparison with Doppler echocardiography.
Journal of Cardiovascular Magnetic Resonance
2010
Automated estimation of aortic strain from steady‐state free‐precession and phase contrast MR images
Magnetic Resonance in Medicine
2009
Local indices of aortic stiffness a magnetic resonance imaging study
2009 36th Annual Computers in Cardiology Conference (CinC)
2009
“ART-FUN”: an integrated software for functional analysis of the aorta
Journal of Cardiovascular Magnetic Resonance